Mp49-20 Potential of a Combined Psa-Zinc Urinary Test for the Detection of Prostate Cancer

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV (MP49)1 May 2024MP49-20 POTENTIAL OF A COMBINED PSA-ZINC URINARY TEST FOR THE DETECTION OF PROSTATE CANCER Sabrina Titti De Cillis, Sergio Occhipinti, Daniele Amparore, Matteo Manfredi, Enrico Checcucci, Alberto Piana, Federico Piramide, Gabriele Volpi, Michele Sica, Paolo Verri, Stefano Granato, Alberto Quara', Edoardo Cisero, Giovanni Busacca, Michele Ortenzi, Marco Colombo, Anca Georgiana Mesterca, Cecilia Gatti, Andrea Sterrantino, Davide Garino, Nadia Ziani, Michele Di Dio, Cristian Fiori, and Francesco Porpiglia Sabrina Titti De CillisSabrina Titti De Cillis , Sergio OcchipintiSergio Occhipinti , Daniele AmparoreDaniele Amparore , Matteo ManfrediMatteo Manfredi , Enrico CheccucciEnrico Checcucci , Alberto PianaAlberto Piana , Federico PiramideFederico Piramide , Gabriele VolpiGabriele Volpi , Michele SicaMichele Sica , Paolo VerriPaolo Verri , Stefano GranatoStefano Granato , Alberto Quara'Alberto Quara' , Edoardo CiseroEdoardo Cisero , Giovanni BusaccaGiovanni Busacca , Michele OrtenziMichele Ortenzi , Marco ColomboMarco Colombo , Anca Georgiana MestercaAnca Georgiana Mesterca , Cecilia GattiCecilia Gatti , Andrea SterrantinoAndrea Sterrantino , Davide GarinoDavide Garino , Nadia ZianiNadia Ziani , Michele Di DioMichele Di Dio , Cristian FioriCristian Fiori , and Francesco PorpigliaFrancesco Porpiglia View All Author Informationhttps://doi.org/10.1097/01.JU.0001008696.31772.28.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of this study is to find out if the combined analisys of urinary levels of PSA (uPSA) plus urinary Zinc (uZinc) could have a role in identify men with PCa among candidates for prostate biopsy. METHODS: Urine samples after prostatic massages were collected from patients with suspected prostate cancer scheduled for prostate biopsy at our Institution. Quantification of uPSA was performed by ECLIA platform and confirmed by ELISA essay, while uZinc measurement was evaluated by atomic absorption and confirmed by colorimetric in vitro assay. On the basis of these assays, a Urine Score (uScore) was assigned to each urine sample as follow: 2 (both markers positive), 1 (only one marker positive), 0 (both markers negative). Six multivariate logistic regression analysis were performed to assess diagnostic performance of uScore, SOC (serum PSA, DRE, age) and MRI alone, end of MRI+SOC, MRI+uScore and MRI+uScore+SOC. The discriminative power of the logistic models was assessed by calculating the area under the receiver operating characteristic (ROC) curves (AUC). RESULTS: 238 patients were enrolled in the study. 145 subjects were diagnosed with PCa (called hereafter CP), whereas remaining 93 subjects were free from disease (healthy subjects, HS). Median urine PSA and Zinc after prostatic massage was lower in CP than in HS. Moreover, there was an inverse correlation between the concentration of both urinary molecules and the tumour grade group. We identified the optimal cutoff for both urinary PSA and Zinc that maximize the discrimination between CP and HS in term of sensitivity and specificity. Multivariate ROC curve analysis combining uScore with SOC and MRI resulted in an AUC=0.882, that is statistically different from SOC or MRI alone, or SOC+MRI (p=0.0001, p=0.0001, and p=0.008 respectively) (Figure 1). Prostate Cancer risk algorithm designed considering uScore, SOC and MRI results in potential reduction of 57% of unnecessary biopsies. CONCLUSIONS: The loss of PSA and Zinc production and secretion by the prostate during neoplastic transformation could potentially represent a hallmark of PCa, and its combination with standard diagnostic parameters and mpMRI could represent an interesting approach in the diagnosis of PCa. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e791 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Sabrina Titti De Cillis More articles by this author Sergio Occhipinti More articles by this author Daniele Amparore More articles by this author Matteo Manfredi More articles by this author Enrico Checcucci More articles by this author Alberto Piana More articles by this author Federico Piramide More articles by this author Gabriele Volpi More articles by this author Michele Sica More articles by this author Paolo Verri More articles by this author Stefano Granato More articles by this author Alberto Quara' More articles by this author Edoardo Cisero More articles by this author Giovanni Busacca More articles by this author Michele Ortenzi More articles by this author Marco Colombo More articles by this author Anca Georgiana Mesterca More articles by this author Cecilia Gatti More articles by this author Andrea Sterrantino More articles by this author Davide Garino More articles by this author Nadia Ziani More articles by this author Michele Di Dio More articles by this author Cristian Fiori More articles by this author Francesco Porpiglia More articles by this author Expand All Advertisement PDF downloadLoading ...