Mp56-14 the Impact of Histological Variants on Oncological Outcomes After Surgical Resection of a Nonmetastatic Renal Cell Carcinoma With Tumor Thrombus: A Multi-Institutional Study

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy IV (MP56)1 May 2024MP56-14 THE IMPACT OF HISTOLOGICAL VARIANTS ON ONCOLOGICAL OUTCOMES AFTER SURGICAL RESECTION OF A NONMETASTATIC RENAL CELL CARCINOMA WITH TUMOR THROMBUS: A MULTI-INSTITUTIONAL STUDY Zine-Eddine Khene, Raphael Fleury, Pierre Bigot, Morgan Roupret, Jean-Christophe Bernhard, Francois Audenet, Thibaut Waeckel, Bastien Parier, Cecile Champy, Jonathan Olivier, Nicolas Doumerc, Thibault Tricard, Nicolas Branger, Franck Bruyere, Louis Surlemont, Romain Boissier, Jean Jacques Patard, Idir Ouzaid, and Karim Bensalah Zine-Eddine KheneZine-Eddine Khene , Raphael FleuryRaphael Fleury , Pierre BigotPierre Bigot , Morgan RoupretMorgan Roupret , Jean-Christophe BernhardJean-Christophe Bernhard , Francois AudenetFrancois Audenet , Thibaut WaeckelThibaut Waeckel , Bastien ParierBastien Parier , Cecile ChampyCecile Champy , Jonathan OlivierJonathan Olivier , Nicolas DoumercNicolas Doumerc , Thibault TricardThibault Tricard , Nicolas BrangerNicolas Branger , Franck BruyereFranck Bruyere , Louis SurlemontLouis Surlemont , Romain BoissierRomain Boissier , Jean Jacques PatardJean Jacques Patard , Idir OuzaidIdir Ouzaid , and Karim BensalahKarim Bensalah View All Author Informationhttps://doi.org/10.1097/01.JU.0001008940.44711.d4.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There is no definitive evidence regarding the prognostic impact of histological variants (HVs) in patient who undergo surgical resection of a non-metastatic renal cell carcinoma (nm-RCC) with venous tumor thrombus (TT). The objective was to investigate the impact of HVs on the prognosis of patients with nm-RCC with TT after radical surgery. METHODS: Patients who underwent radical nephrectomy with removal of venous TT for a non-metastatic RCC were included in a retrospective study. Three groups were identified: clear cell carcinomas (ccCCR), papillary carcinomas (pCCR), and chromophobe carcinomas (chCCR). The primary outcome measures (disease-free survival and overall survival) were assessed using the Kaplan-Meier method and compared using the Log-Rank test. Univariate and multivariate Cox proportional hazards models were used to study the impact of histological variant on survival. RESULTS: A total of 873 patients were included. Histological subtypes were ccRCC, pRCC, and chRCC, accounting for 89%, 7%, and 4% of cases, respectively. At the time of data analysis, 612 (70%) patients were recurrence-free, and 228 had died (26%). Survival analysis showed a significant difference based on histological subtypes, with the worst survival outcomes for pRCC (p<0.05). In multivariable analysis, the presence of pRCC was independently associated with both DFS and OS (HR: 1.62; p=0.02 and HR: 1.76; p=0.03). Limitations include the retrospective nature of the study. CONCLUSIONS: In this multicentric series, histological variant appeared to impact the medium-term oncological prognosis of kidney cancer with tumor thrombus. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e932 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Zine-Eddine Khene More articles by this author Raphael Fleury More articles by this author Pierre Bigot More articles by this author Morgan Roupret More articles by this author Jean-Christophe Bernhard More articles by this author Francois Audenet More articles by this author Thibaut Waeckel More articles by this author Bastien Parier More articles by this author Cecile Champy More articles by this author Jonathan Olivier More articles by this author Nicolas Doumerc More articles by this author Thibault Tricard More articles by this author Nicolas Branger More articles by this author Franck Bruyere More articles by this author Louis Surlemont More articles by this author Romain Boissier More articles by this author Jean Jacques Patard More articles by this author Idir Ouzaid More articles by this author Karim Bensalah More articles by this author Expand All Advertisement PDF downloadLoading ...