What question did this study set out to answer?

The research aims to uncover genetic variants associated with pulmonary function and COPD across diverse ancestries.

January 17, 2026Open Access

Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants

WKWonji KimBrigham and Women's Hospital DXDan XieUniversity of Virginia Health System KKKangjin KimGachon University

Key Points

The research aims to uncover genetic variants associated with pulmonary function and COPD across diverse ancestries.
Conducted whole genome sequencing (WGS) on 44,287 multi-ancestry participants.
Analyzed genetic variants related to lung function measurements.
Investigated biological pathways associated with COPD.
Identified novel genetic variants linked to lung function impairment.
Highlighted biologically relevant genes and pathways involved in COPD.
Enhanced fine-mapping resolution for understanding genetic influences on pulmonary health.

Abstract

Large-scale multi-ancestry WGS analysis improves variant discovery and fine-mapping resolution for lung function and COPD and highlights biologically relevant genes and pathways.

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