The research aims to uncover genetic variants associated with pulmonary function and COPD across diverse ancestries.
Conducted whole genome sequencing (WGS) on 44,287 multi-ancestry participants.
Analyzed genetic variants related to lung function measurements.
Investigated biological pathways associated with COPD.
Identified novel genetic variants linked to lung function impairment.
Highlighted biologically relevant genes and pathways involved in COPD.
Enhanced fine-mapping resolution for understanding genetic influences on pulmonary health.
Abstract
Large-scale multi-ancestry WGS analysis improves variant discovery and fine-mapping resolution for lung function and COPD and highlights biologically relevant genes and pathways.