What question did this study set out to answer?

To investigate the epidemiology and outcomes of intra-abdominal infections in ICU patients and identify factors leading to mortality.

January 22, 2026Journal of Anesthesia Analgesia and Critical Care2 citationsOpen Access

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Epidemiology and outcome of intra-abdominal infections in intensive care unit in Italy from the Italian Register of complicated Intra-abdominal InfectionS—the IRIS study: a prospective observational nationwide study

EBEtrusca BrogiUniversity of Pisa CCCamilla Cremonini MCMarco Ceresoli

Key Points

To investigate the epidemiology and outcomes of intra-abdominal infections in ICU patients and identify factors leading to mortality.
Conducted a nationwide observational study across ICUs in Italy.
Analyzed data from the Italian Register of complicated Intra-abdominal Infections (IRIS).
Evaluated patient risk factors associated with in-hospital mortality.
Septic shock is the leading cause of ICU admissions for intra-abdominal infections.
Immunosuppression and serious comorbidities significantly increase the risk of mortality.
Modifiable factors such as timely intervention and effective source control can improve patient outcomes.

Abstract

Septic shock remains the leading cause of ICU admission in patients with IAIs. Patients with immunosuppression, serious cardiovascular comorbidities, requirement for re-operation, inadequate source control, peritonitis, and healthcare-associated infections were at significantly higher risk of in-hospital mortality. Overall, our study reinforces the multifactorial nature of mortality in critically ill patients with intra-abdominal infections, highlighting modifiable factors (source control, timely intervention) that can be targeted to improve outcomes.

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Cite This Study

Brogi et al. (Tue,) studied this question.

synapsesocial.com/papers/6971be6b642b1836717e310a https://doi.org/https://doi.org/10.1186/s44158-026-00338-2

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