Association between aerobic exercise and vascular endothelial growth factor (VEGF) concentration in adults: a systematic review and meta-analysis of randomized controlled trials

Key Points

• Investigate the influence of aerobic exercise on circulating VEGF concentrations in adults.
• Conducted systematic review and meta-analysis of randomized controlled trials
• Analyzed the effects of aerobic exercise interventions on VEGF levels
• Explored the duration of interventions and their impact on results
• No significant overall influence of aerobic exercise on VEGF levels found
• Short-duration interventions may lead to reductions in VEGF
• Calls for further high-quality RCTs to confirm findings and explore underlying mechanisms