Rapid quantification of bile acids in serum by LC-MS/MS and application to serum bile acid profile in voriconazole administered patients with invasive fungal infections | Synapse
February 8, 2026
Rapid quantification of bile acids in serum by LC-MS/MS and application to serum bile acid profile in voriconazole administered patients with invasive fungal infections
Key Points
To evaluate a novel LC-MS/MS method for quantifying bile acids in human serum.
Developed a rapid LC-MS/MS technique for analyzing 30 bile acids.
Applied the method to serum samples from patients receiving voriconazole for invasive fungal infections.
Assessed liver function through bile acid profiling in patient samples.
Successfully quantified 30 bile acids in human serum.
Demonstrated potential use for evaluating liver function in clinical settings.
Abstract
This LC-MS/MS method for the quantification of 30 bile acids in human serum might apply a new analytical approach for liver function evaluation.