Rapid quantification of bile acids in serum by LC-MS/MS and application to serum bile acid profile in voriconazole administered patients with invasive fungal infections

Key Points

• To evaluate a novel LC-MS/MS method for quantifying bile acids in human serum.
• Developed a rapid LC-MS/MS technique for analyzing 30 bile acids.
• Applied the method to serum samples from patients receiving voriconazole for invasive fungal infections.
• Assessed liver function through bile acid profiling in patient samples.
• Successfully quantified 30 bile acids in human serum.
• Demonstrated potential use for evaluating liver function in clinical settings.