Antioxidant efficacy of Cotoneaster nummularius in phenylhydrazine-induced hyperbilirubinemia: A rat model study.

Key Points

• The aim is to assess the antioxidant efficacy of C. nummularius extract against phenylhydrazine-induced hyperbilirubinemia in a rat model.
• Administered C. nummularius extract at varying doses (5 mg/kg) to assess effects on liver function.
• Induced hyperbilirubinemia using phenylhydrazine in rats to model oxidative damage.
• Measured levels of bilirubin and oxidative stress markers in liver tissue.
• C. nummularius extract significantly reduced bilirubin levels in a dose-dependent manner.
• Antioxidant activity was notably highest at the 5 mg/kg dosage.
• The extract demonstrated potential hepatoprotective effects against oxidative stress.