Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs

Key Points

• To develop efficient methods for synthesizing diverse substituted pyrimidines using copper-catalyzed reactions.
• Utilized copper catalysts to control reactions of 2H-azirines with TosMICs.
• Developed two distinct reaction pathways for modular synthesis.
• Focused on non electron-withdrawing substituents at position 4 of pyrimidines.
• Successfully synthesized a variety of substituted pyrimidines.
• Demonstrated efficiency and modularity of the copper-catalyzed approach.
• Results indicate potential for broad applications in organic synthesis.