Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs

Wen Cheng; MengFan Li; Hao Tang; Yuxi Wang; qiurou yu; Xiaoli Bao; Yun‐Hui Zhao; Weiyin Yi

doi:10.1039/d5ob01962a

January 1, 2025Organic & Biomolecular Chemistry

Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs

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Key Points

To develop efficient methods for synthesizing diverse substituted pyrimidines using copper-catalyzed reactions.
Utilized copper catalysts to control reactions of 2H-azirines with TosMICs.
Developed two distinct reaction pathways for modular synthesis.
Focused on non electron-withdrawing substituents at position 4 of pyrimidines.
Successfully synthesized a variety of substituted pyrimidines.
Demonstrated efficiency and modularity of the copper-catalyzed approach.
Results indicate potential for broad applications in organic synthesis.

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Implication

Developed copper-controlled reactions provide efficient pathways to produce diverse pyrimidines, indicating broad synthetic utility.

Abstract

Two copper-controlled reactions of 2H-azirines with TosMICs have been developed that provide two efficient and modular approachs to diverse substituted pyrimidines with non electron-withdrawing substituents at the position 4 or...

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Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/698d6e4a5be6419ac0d53ecd https://doi.org/10.1039/d5ob01962a

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Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Synthesis of Diverse Substituted Pyrimidines through Cu Catalyst-Controlled Ts Group's Elimination and Reinsertion Pathway from 2H-Azirines with TosMICs

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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