What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To compare the effectiveness of photon and proton radiotherapy in increasing functional survival in adults with primary brain tumors.

February 16, 2026Open Access

Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE)

Key Points

To compare the effectiveness of photon and proton radiotherapy in increasing functional survival in adults with primary brain tumors.
Phase 3 randomized controlled trial design
Enrollment of adults with primary brain tumors
Comparison of outcomes between photon and proton radiotherapy
Ethics approval obtained from Tata Memorial Centre, Mumbai
Trial registered in Clinical Trial Registry of India and Clinicaltrials.gov.
Functional survival outcomes will be evaluated between the two treatment groups
Statistical analysis will assess the effectiveness of treatment types

Abstract

The trial has been approved by the Institutional Ethics Committee of Tata Memorial Centre, Mumbai. The trial has been registered with the Clinical Trial Registry of India (CTRI/2025/03/082568) and Clinicaltrials.gov (study identifier NCT06831461).

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Cite This Study

Dasgupta et al. (Sat,) studied this question.

synapsesocial.com/papers/69926575eb1f82dc367a14aa https://doi.org/https://doi.org/10.1186/s13014-025-02785-7

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