Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE)

Q: What type of study is this?

This is a Pre-Registered Trial study.

Archya Dasgupta; S. Ghosh; Abhishek Chatterjee; Sadhana Kannan; Savita Goswami; C. P. Ranjith; Rohidas Punde; Lilawati Meena; Prakash Shinde; Manimala Konthoujam; R. Phurailatpam; Avdhoot Sutar; Divya Patil; A Sahu; Epari Sridhar; Aliasgar Moiyadi; Nandini Menon; Ameya Puranik; Nazia Bano; Tejpal Gupta

doi:10.1186/s13014-025-02785-7

Key Points

To compare the effectiveness of photon and proton radiotherapy in increasing functional survival in adults with primary brain tumors.
Phase 3 randomized controlled trial design
Enrollment of adults with primary brain tumors
Comparison of outcomes between photon and proton radiotherapy
Ethics approval obtained from Tata Memorial Centre, Mumbai
Trial registered in Clinical Trial Registry of India and Clinicaltrials.gov.
Functional survival outcomes will be evaluated between the two treatment groups
Statistical analysis will assess the effectiveness of treatment types

Implication

Phase 3 randomized controlled trial evaluates photon and proton radiotherapy for brain tumors, suggesting implications for functional survival.

Abstract

The trial has been approved by the Institutional Ethics Committee of Tata Memorial Centre, Mumbai. The trial has been registered with the Clinical Trial Registry of India (CTRI/2025/03/082568) and Clinicaltrials.gov (study identifier NCT06831461).

Discussion

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Cite This Study

Dasgupta et al. (2026) studied this question.

synapsesocial.com/papers/69926575eb1f82dc367a14aa https://doi.org/10.1186/s13014-025-02785-7

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Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE)

Key Points

Implication

Abstract

Discussion

Cite This Study

Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE)

Key Points

Implication

Abstract

Discussion

Cite This Study

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