The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Key Points

• To explore the complex roles of human chorionic gonadotropin in the central nervous system, balancing its beneficial and harmful effects.
• Review existing literature on hCG's functions in the CNS
• Analyze mechanistic hypotheses related to neuroprotection and neurotoxicity
• Identify knowledge gaps for future research
• hCG is essential for reproductive and immune functions
• Under certain conditions, hCG may exhibit neurotoxic effects
• Need for longitudinal and experimental studies to confirm its role in CNS health