The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Seyedehmaryam Hosseini; Pedram Ghanavati; Tayebeh Esfidani; Nadia Talati Reveshti; Hanie Babaei; Atoosa Etezadi

doi:10.1007/s00404-025-08251-9

February 14, 2026Archives of Gynecology and ObstetricsOpen Access

The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

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Key Points

To explore the complex roles of human chorionic gonadotropin in the central nervous system, balancing its beneficial and harmful effects.
Review existing literature on hCG's functions in the CNS
Analyze mechanistic hypotheses related to neuroprotection and neurotoxicity
Identify knowledge gaps for future research
hCG is essential for reproductive and immune functions
Under certain conditions, hCG may exhibit neurotoxic effects
Need for longitudinal and experimental studies to confirm its role in CNS health

Implication

This review synthesizes mechanistic hypotheses on hCG's neuroprotective and potential neurotoxic effects in the CNS, suggesting further investigation is necessary.

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Cite This Study

Hosseini et al. (2026) studied this question.

synapsesocial.com/papers/699405254e9c9e835dfd5f5e https://doi.org/10.1007/s00404-025-08251-9

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The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Key Points

Implication

Abstract

Discussion

Cite This Study

The dual face of human chorionic gonadotropin in the CNS: neuroprotection, signaling, and possible pathological effects

Key Points

Implication

Abstract

Discussion

Cite This Study

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