What question did this study set out to answer?

To assess the relationship between telomere length and chronic kidney disease (CKD) in the Pakistani population.

February 19, 2026Acta Clinica Belgica0 citations

Impact of telomere length alteration in chronic kidney disease patients of Pakistan: a case–control study and meta-analysis of 24,089 patients

MTMadiha TahirCOMSATS University Islamabad ALAfrose LiaquatShifa Tameer-e-Millat University FKFareeha KhalilShifa Tameer-e-Millat University

Key Points

To assess the relationship between telomere length and chronic kidney disease (CKD) in the Pakistani population.
Conducted a case-control study comparing telomere length in CKD patients and control group.
Performed a meta-analysis involving 24,089 patients to evaluate telomere length's association with CKD.
Analyzed population-specific effects and potential biological aging implications.
Identified a significant association between altered telomere length and CKD prevalence.
Indicated that telomere length may reflect systemic biological aging rather than serving solely as a biomarker.
Longitudinal studies are needed to explore causality and effects specific to the population.

Abstract

LTL is associated with CKD, which may reflect systemic biological aging and disease burden rather than serving as a standalone clinical biomarker. Longitudinal studies are required to clarify causality and population-specific effects.

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