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February 16, 2026Acta Clinica Belgica

Impact of telomere length alteration in chronic kidney disease patients of Pakistan: a case–control study and meta-analysis of 24,089 patients

Madiha Tahir Afrose Liaquat Fareeha Khalil Zuha Tariq Arham Javed Aleezay Irfan Muhammad Jawad Khan

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Key Points

To assess the relationship between telomere length and chronic kidney disease (CKD) in the Pakistani population.
Conducted a case-control study comparing telomere length in CKD patients and control group.
Performed a meta-analysis involving 24,089 patients to evaluate telomere length's association with CKD.
Analyzed population-specific effects and potential biological aging implications.
Identified a significant association between altered telomere length and CKD prevalence.
Indicated that telomere length may reflect systemic biological aging rather than serving solely as a biomarker.
Longitudinal studies are needed to explore causality and effects specific to the population.

Implication

Case-control analysis reveals telomere length's role in chronic kidney disease, suggesting systemic aging implications.

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Cite This Study

Tahir et al. (2026) studied this question.

synapsesocial.com/papers/6996a798ecb39a600b3ed70b https://doi.org/10.1080/17843286.2026.2627250

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1O40 TELOMERE LENGTH AS A BIOMARKER FOR KIDNEY HEALTH: EVIDENCE FROM A MENDELIAN RANDOMISATION STUDY2024
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