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This study aims to evaluate the prognostic value of leukocyte telomere length (LTL) in forecasting long-term mortality among older patients discharged from acute care hospitals.

June 27, 2026GeroScienceOpen Access

Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals

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This study aims to evaluate the prognostic value of leukocyte telomere length (LTL) in forecasting long-term mortality among older patients discharged from acute care hospitals.
876 patients aged ≥ 65 years were analyzed from the Report-AGE cohort.
LTL was measured using quantitative real-time PCR and expressed as age-adjusted residuals.
Cox proportional hazards models were employed to assess associations between LTL and mortality.
Over a median follow-up of 126.8 months, 713 patients died.
Shorter age-adjusted LTL was linked to a higher mortality risk (HR per 1 SD decrease = 1.10; 95% CI 1.02–1.19; p = 0.012).
Shorter-than-expected telomeres showed a significantly higher mortality risk (adjusted HR = 1.30; 95% CI 1.05–1.60; p = 0.016), particularly in non-frail individuals.

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Implication

Prospective observational study shows age-adjusted telomere length predicts mortality in older adults, highlighting biological aging significance.

Cite This Study

Maniscalco et al. (2026) studied this question.

synapsesocial.com/papers/6a3f69a5aea7db3c1954067a https://doi.org/10.1007/s11357-026-02386-6

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Implication

Prospective observational study shows age-adjusted telomere length predicts mortality in older adults, highlighting biological aging significance.

Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals

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Discussion

Implication

Cite This Study

Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals

Key Points

Discussion

Implication

Cite This Study

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