What question did this study set out to answer?

The research aims to explore how body mass index and fetal fraction mediate the relationship between advanced maternal age and the risk of gestational diabetes mellitus.

February 19, 2026Open Access

Mediating role of body mass index and fetal fraction in the association between advanced maternal age and gestational diabetes mellitus risk: a retrospective non-invasive prenatal testing cohort study

Key Points

The research aims to explore how body mass index and fetal fraction mediate the relationship between advanced maternal age and the risk of gestational diabetes mellitus.
Retrospective cohort study
Analysis of non-invasive prenatal testing (NIPT) data
Assessment of body mass index (BMI) and fetal fraction (FF) levels
Advanced maternal age is associated with a higher risk of gestational diabetes mellitus (GDM).
Elevated body mass index (BMI) and reduced fetal fraction (FF) contribute to this increased risk.
Findings suggest that metabolic and placental factors play a significant mediating role.

Abstract

AMA significantly increases GDM risk, partly mediated by elevated BMI and reduced NIPT-derived FF. These findings highlight the role of maternal metabolic and placental factors as key intermediaries in AMA-related GDM, offering insights for targeted prenatal risk stratification and intervention. Given the retrospective design, causal inference cannot be established.

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Cite This Study

张 et al. (Mon,) studied this question.

synapsesocial.com/papers/6996a7d3ecb39a600b3edeb8 https://doi.org/https://doi.org/10.1186/s40001-026-04042-3

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