Retrospective cohort study reveals the impact of BMI and fetal fraction on gestational diabetes risk in advanced maternal age, highlighting metabolic and placental roles.
AMA significantly increases GDM risk, partly mediated by elevated BMI and reduced NIPT-derived FF. These findings highlight the role of maternal metabolic and placental factors as key intermediaries in AMA-related GDM, offering insights for targeted prenatal risk stratification and intervention. Given the retrospective design, causal inference cannot be established.
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张 et al. (2026) studied this question.
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