What question did this study set out to answer?

To identify characteristics in women with gestational diabetes mellitus that predict an increased risk of congenital malformations in their infants.

May 21, 2005Diabetic Medicine

Pre‐gestational maternal body mass index predicts an increased risk of congenital malformations in infants of mothers with gestational diabetes

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Authors

MMMaría Luisa Martínez‐FríasInstituto de Salud Carlos III JFJuan P. FríasRoyal Edinburgh Hospital EBEva BermejoInstituto de Salud Carlos III

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Implication

Case-control study finds pre-pregnancy obesity increases congenital malformation risk in gestational diabetes, suggesting unrecognized pre-gestational diabetes may drive fetal defects.

Key Points

To identify characteristics in women with gestational diabetes mellitus that predict an increased risk of congenital malformations in their infants.
Analyzed data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), a hospital-based case-control study and surveillance system.
Evaluated the association between pre-gestational body mass index (obesity defined as BMI ≥ 30 kg/m²) and infant congenital malformations among women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
Infants of obese mothers with GDM had an increased overall risk for selected congenital malformations compared to those of obese mothers with NGT (risk ratio = 2.78, 95% CI 1.38–5.55, P < 0.001).
Within the GDM cohort, maternal obesity was significantly associated with cardiovascular defects compared to non-obese mothers (OR = 2.82, 95% CI 1.31–7.04, P < 0.01).
Pre-gestational BMI showed no association with congenital malformations in mothers with normal glucose tolerance.

Cite This Study

Martínez‐Frías et al. (2005) studied this question.

synapsesocial.com/papers/6a0f9de0d03631df9ce9cd1c https://doi.org/10.1111/j.1464-5491.2005.01492.x

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Implication

Case-control study finds pre-pregnancy obesity increases congenital malformation risk in gestational diabetes, suggesting unrecognized pre-gestational diabetes may drive fetal defects.

Pre‐gestational maternal body mass index predicts an increased risk of congenital malformations in infants of mothers with gestational diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Pre‐gestational maternal body mass index predicts an increased risk of congenital malformations in infants of mothers with gestational diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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