What question did this study set out to answer?

To highlight the phenomenon of rapidly fluctuating creatinine levels leading to a false diagnosis of acute kidney injury.

February 22, 2026

Creatinine chaos: a case of pseudo- acute kidney injury after iv dexamethasone

Key Points

To highlight the phenomenon of rapidly fluctuating creatinine levels leading to a false diagnosis of acute kidney injury.
Case report of a patient with high serum creatinine levels that normalized quickly after treatment with IV dexamethasone.
Immediate serum creatinine normalization within an hour after administration of dexamethasone.
Initial diagnosis indicated acute kidney injury due to elevated creatinine levels.

Abstract

Introduction: Serum creatinine is routinely used to diagnose acute kidney injury (AKI). Artifactually elevated creatinine can lead to a false AKI diagnosis and inappropriate actions. Rapidly fluctuating creatinine concentrations are unusual. We describe a case where a very high serum creatinine normalised within an hour, prompting investigation of possible causes.

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