Method for Producing 5-Cyano-2-Methyl--(2-Methylphenyl)-4-(4-Nitrophenyl)-6-Thioxo-1,6-Dihydropyridine-3-Carboxamide Derivatives

Key Points

• To synthesize derivatives of 5-cyano-2-methyl-dihydropyridine through multicomponent reactions.
• Utilized multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, and alkyl halides.
• Conducted reactions by boiling in ethanol with potassium hydroxide as a catalyst.
• Employed specific ratios of reactants to optimize product yield.
• Achieved yields of 64–91% for the target thioxo-dihydropyridine derivatives.
• Synthesized 2-alkylthiopyridines and 3-aminothieno[2,3-]pyridines as key products.