This process demonstrates the synthesis of thioxo-dihydropyridine derivatives, indicating a new approach in organic compounds.
The multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, -(2-methylphenyl)-3-oxobutanamide and alkyl halides upon boiling in ethanol in the presence of twice the amount of potassium hydroxide produced derivatives of 5-cyano-2-methyl--(2-methylphenyl)-4-(4-nitrophenyl)-6-thioxo-1,6-dihydropyridine-3-carboxamide – 2-alkylthiopyridines and 3-aminothieno[2,3-]pyridines, with yields of 64–91%.
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B.S. Krivokolysko (2025) studied this question.
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