December 31, 2018
Racial Differences in Ischaemia/Bleeding Risk Trade-Off during Anti-Platelet Therapy: Individual Patient Level Landmark Meta-Analysis from Seven RCTs
Structured PICO
Does prolonged DAPT affect the ischaemia/bleeding risk trade-off differently in East Asians compared to non-East Asians?
P
Population
East Asians and non-East Asians receiving anti-platelet therapy (pooled from 7 RCTs)
I
Intervention
Prolonged dual anti-platelet therapy (DAPT)
O
Outcome
Ischaemic risk and bleeding riskhard clinical
Prolonged DAPT in East Asians may not reduce ischaemic risk but significantly increases bleeding risk, highlighting important racial differences in anti-platelet therapy trade-offs.
Abstract
We suggest that the ischaemia/bleeding trade-off may be different between East Asians and non-East Asians. In East Asians, prolonged DAPT may have no effect in reducing the ischaemic risk, while significantly increases the bleeding risk.
Cite This Study
Kang et al. (Mon,) studied this question.