PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
December 31, 2018Thrombosis and Haemostasis160 citations

Racial Differences in Ischaemia/Bleeding Risk Trade-Off during Anti-Platelet Therapy: Individual Patient Level Landmark Meta-Analysis from Seven RCTs

JKJeehoon KangKPKyung Sik ParkTPTullio Palmerini

Structured PICO

Does prolonged DAPT affect the ischaemia/bleeding risk trade-off differently in East Asians compared to non-East Asians?

P
Population
East Asians and non-East Asians receiving anti-platelet therapy (pooled from 7 RCTs)
I
Intervention
Prolonged dual anti-platelet therapy (DAPT)
O
Outcome
Ischaemic risk and bleeding riskhard clinical

Prolonged DAPT in East Asians may not reduce ischaemic risk but significantly increases bleeding risk, highlighting important racial differences in anti-platelet therapy trade-offs.

Abstract

We suggest that the ischaemia/bleeding trade-off may be different between East Asians and non-East Asians. In East Asians, prolonged DAPT may have no effect in reducing the ischaemic risk, while significantly increases the bleeding risk.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Kang et al. (2018) studied this question.

synapsesocial.com/papers/69a30061efb2b0e59c0a3e63https://doi.org/10.1055/s-0038-1676545
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A shorter duration of dual-antiplatelet therapy following percutaneous coronary intervention by region of study: a meta-analysis of randomized clinical trials2025
  2. 2Impact of ethnicity on antiplatelet treatment regimens for bleeding reduction in acute coronary syndromes: a systematic review and pre-specified subgroup meta-analysis2023 · 34 citations
  3. 3De-escalation of antiplatelet therapy after percutaneous coronary intervention among East Asians and non-East Asians: a meta-analysis of randomized controlled trials2022 · 16 citations
  4. 4Should Antithrombotic Treatment Strategies in East Asians Differ from Caucasians?2018 · 41 citations
  5. 5Efficacy and Safety of Long-Term and Short-Term Dual Antiplatelet Therapy: A Meta-Analysis of Comparison between Asians and Non-Asians2020 · 12 citations