Triangulating Associations Between Fruit Intake and Lung Cancer Risk: Evidence from GBD Estimates, Mendelian Randomization, and Real-World Validation.

Key Points

• This study aims to explore the relationship between fruit intake and lung cancer risk using multiple approaches.
• Analyzed population-level data from Global Burden of Disease estimates
• Utilized mendelian randomization to assess genetic associations
• Conducted clinical validations of findings
• Insufficient fruit intake is consistently linked to increased lung cancer risk
• Findings are supported across different data sources
• Strength of association indicates a potential modifiable risk factor