Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

Key Points

• The interaction between rifampin and linezolid was primarily mediated by the ABCB1 transporter, which is a key finding.
• High-dose rifampin significantly alters linezolid plasma exposure, similar to effects from standard dosing.
• Assessment utilized physiologically-based pharmacokinetic modelling to analyze drug interactions.
• Findings highlight the importance of transporter interactions in medication management and dosage adjustments.