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Observational analysis suggests ABCB1 mediates rifampin-linezolid interaction, indicating a critical pharmacokinetic concern.
Our study suggested that ABCB1 is the primary transporter responsible for the interaction between rifampin and linezolid. The DDI effect of high-dose rifampin on linezolid plasma exposure is similar to that of standard-dose rifampin.
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Nguyen et al. (2026) studied this question.
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