Muscle-specific transcriptomic and metabolomic signatures reveal heterogeneous aging trajectories and altered intercellular communication in male murine skeletal muscle

Key Points

• Aging trajectories reveal distinct patterns in skeletal muscle, impacting overall functionality and health.
• Key metrics of transcriptomic and metabolomic profiles show variations linked to age in 5 distinct markers.
• Observational analysis of murine skeletal muscle examines transcriptomic and metabolomic changes over time.
• Findings highlight the complexity of aging, indicating that intercellular communication may be significantly altered.