Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models. | Synapse
March 4, 2026
Mechanistic insight into the anti-inflammatory and lung-protective effects of Agrimonia pilosa extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models.
Key Points
The research aims to explore how Agrimonia pilosa extract affects inflammation in lung diseases.
Used ovalbumin- and lipopolysaccharide-induced models to simulate respiratory inflammation.
Measured NF-κB and MAPK signaling pathways as indicators of inflammation.
Analyzed the effects on proteolysis and apoptosis in lung tissues.
Agrimonia pilosa extract significantly inhibited NF-κB and MAPK signaling.
It decreased markers of inflammation and improved lung function in models.
Regulation of proteolysis and apoptosis was observed, supporting lung protection.
Abstract
AP exhibits anti-inflammatory and lung-protective effects by inhibiting NF-κB/MAPK signaling and regulating proteolysis and apoptosis, indicating it as a safe, effective treatment for airway inflammation.