What does this research mean for the field?

Hand-dominant joint involvement pattern is associated with a favorable treatment response, while polyarthritis is associated with an unfavorable response to both csDMARDs and bDMARDs in early rheumatoid arthritis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

Assess how joint involvement patterns correlate with treatment responses to csDMARDs and bDMARDs in early rheumatoid arthritis.

March 12, 2026Open Access

Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials

Key Points

Assess how joint involvement patterns correlate with treatment responses to csDMARDs and bDMARDs in early rheumatoid arthritis.
Combined analysis of NORD-STAR and BeSt trials
Evaluated treatment responses to conventional and biological disease-modifying antirheumatic drugs (csDMARDs and bDMARDs)
Compared outcomes based on hand-dominant joint involvement (JIP-Hand) versus polyarthritis (JIP-Poly).
JIP-Hand showed the greatest improvement in disease activity with both csDMARDs and bDMARDs.
JIP-Poly exhibited the least improvement in disease activity with both treatment types.

Abstract

In early RA, csDMARD and bDMARD treatments resulted in the greatest improvement in disease activity in JIP-Hand and the least improvement in JIP-Poly.

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Cite This Study

Nagafuchi et al. (Sun,) studied this question.

synapsesocial.com/papers/69b2575e96eeacc4fcec5e8d https://doi.org/https://doi.org/10.1016/j.ard.2026.02.005

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