Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials

Q: What does this research mean for the field?

Hand-dominant joint involvement pattern is associated with a favorable treatment response, while polyarthritis is associated with an unfavorable response to both csDMARDs and bDMARDs in early rheumatoid arthritis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Yasuo Nagafuchi; Tjardo D. Maarseveen; Kristina Lend; Anna Rudin; Bjorn Gudbjornsson; Dan Nordström; Espen A. Haavardsholm; G. Gröndal; Jon Lampa; Kim Hørslev Petersen; Marte Schrumpf Heiberg; Merete Hetland; Mike T. Nurmohamed; Mikkel Østergaard; Ronald van Vollenhoven; T. Uhlig; Tuulikki Sokka-Isler; Erik B. van den Akker; Tom W.J. Huizinga; Sytske Anne Bergstra; Rachel Knevel

doi:10.1016/j.ard.2026.02.005

Key Points

Assess how joint involvement patterns correlate with treatment responses to csDMARDs and bDMARDs in early rheumatoid arthritis.
Combined analysis of NORD-STAR and BeSt trials
Evaluated treatment responses to conventional and biological disease-modifying antirheumatic drugs (csDMARDs and bDMARDs)
Compared outcomes based on hand-dominant joint involvement (JIP-Hand) versus polyarthritis (JIP-Poly).
JIP-Hand showed the greatest improvement in disease activity with both csDMARDs and bDMARDs.
JIP-Poly exhibited the least improvement in disease activity with both treatment types.

Implication

Combined analysis shows that joint involvement patterns influence treatment response in early rheumatoid arthritis, suggesting tailored approaches.

Abstract

In early RA, csDMARD and bDMARD treatments resulted in the greatest improvement in disease activity in JIP-Hand and the least improvement in JIP-Poly.

Discussion

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Cite This Study

Nagafuchi et al. (2026) studied this question.

synapsesocial.com/papers/69b2575e96eeacc4fcec5e8d https://doi.org/10.1016/j.ard.2026.02.005

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Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials

Key Points

Implication

Abstract

Discussion

Cite This Study

Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials

Key Points

Implication

Abstract

Discussion

Cite This Study

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