Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways | Synapse
March 13, 2026
Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways
Key Points
This research aims to evaluate the protective effects of melatonin and selenium nanoparticles against kidney damage caused by cisplatin.
Co-administration of melatonin and selenium nanoparticles
Assessment of kidney function
Analysis of Nrf2/HO-1 and Bax/Bcl-2 signaling pathways
Significant reduction in nephrotoxic effects of cisplatin
Enhanced activation of Nrf2/HO-1 pathway
Inhibition of pro-apoptotic Bax and promotion of anti-apoptotic Bcl-2
Abstract
The co-administration of Mel and SeNPs demonstrated a significant synergistic effect in protecting the kidneys from Cis-induced nephrotoxicity.