Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways

Key Points

• This research aims to evaluate the protective effects of melatonin and selenium nanoparticles against kidney damage caused by cisplatin.
• Co-administration of melatonin and selenium nanoparticles
• Assessment of kidney function
• Analysis of Nrf2/HO-1 and Bax/Bcl-2 signaling pathways
• Significant reduction in nephrotoxic effects of cisplatin
• Enhanced activation of Nrf2/HO-1 pathway
• Inhibition of pro-apoptotic Bax and promotion of anti-apoptotic Bcl-2