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March 10, 2026Archives of Physiology and Biochemistry

Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways

Faten Zahran Nashwa Barakat ehab saber Ismail Salma M. Khirallah

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Key Points

This research aims to evaluate the protective effects of melatonin and selenium nanoparticles against kidney damage caused by cisplatin.
Co-administration of melatonin and selenium nanoparticles
Assessment of kidney function
Analysis of Nrf2/HO-1 and Bax/Bcl-2 signaling pathways
Significant reduction in nephrotoxic effects of cisplatin
Enhanced activation of Nrf2/HO-1 pathway
Inhibition of pro-apoptotic Bax and promotion of anti-apoptotic Bcl-2

Implication

Co-administration of melatonin and selenium nanoparticles protects against nephrotoxicity, indicating potential therapeutic strategies.

Abstract

The co-administration of Mel and SeNPs demonstrated a significant synergistic effect in protecting the kidneys from Cis-induced nephrotoxicity.

Discussion

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Cite This Study

Zahran et al. (2026) studied this question.

synapsesocial.com/papers/69b3ab5e02a1e69014ccc36e https://doi.org/10.1080/13813455.2026.2640881

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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