Nutritional-inflammatory indices optimize the diagnostic performance of FIB-4 for advanced fibrosis/cirrhosis in patients with benign liver disease

Key Points

• To evaluate how nutritional-inflammatory indices can enhance the diagnostic efficacy of FIB-4 in assessing advanced fibrosis and cirrhosis.
• Comparison of FIB-4 alone versus combination with nutritional indices
• Analysis of sensitivity and specificity in diagnostic performance
• Evaluation of sequential and parallel strategies for optimal results
• FIB-4 alone is suitable for high sensitivity
• Sequential strategy (FIB-4 + PAR and PNI) recommended for high specificity
• Parallel strategy (FIB-4 + PAR or PNI) yields balanced performance