What does this research mean for the field?

Increased circulating levels and altered activity of MMP-2 and TIMP-2 are associated with cardiac remodeling and systolic dysfunction in patients with hypertrophic cardiomyopathy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2004Open Access

Increased Circulating Matrix Metalloproteinase-2 in Patients With Hypertrophic Cardiomyopathy With Systolic Dysfunction

Structured PICO

Population

Patients with hypertrophic cardiomyopathy (HCM) with systolic dysfunction

Outcome

Cardiac remodelingsurrogate

Circulating MMP-2 and TIMP-2 levels may be associated with the mechanisms of cardiac remodeling in patients with hypertrophic cardiomyopathy.

Abstract

These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM.

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