Increased Circulating Matrix Metalloproteinase-2 in Patients With Hypertrophic Cardiomyopathy With Systolic Dysfunction

Q: What does this research mean for the field?

Increased circulating levels and altered activity of MMP-2 and TIMP-2 are associated with cardiac remodeling and systolic dysfunction in patients with hypertrophic cardiomyopathy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yoshihiro Noji; Masami Shimizu; Hidekazu Ino; Toshinori Higashikata; Masato Yamaguchi; Atsushi Nohara; Takahiro Horita; Kuniyoshi Shimizu; Yuji Ito; Takeshi Matsuda; Masanobu Namura; Hiroshi Mabuchi

doi:10.1253/circj.68.355

January 1, 2004Circulation JournalOpen Access

Increased Circulating Matrix Metalloproteinase-2 in Patients With Hypertrophic Cardiomyopathy With Systolic Dysfunction

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Structured PICO

P

Population

Patients with hypertrophic cardiomyopathy (HCM) with systolic dysfunction

O

Outcome

Cardiac remodelingsurrogate

Implication

Circulating MMP-2 and TIMP-2 levels may be associated with the mechanisms of cardiac remodeling in patients with hypertrophic cardiomyopathy.

Abstract

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Cite This Study

Noji et al. (2004) studied this question.

synapsesocial.com/papers/69bc1f01cd265641a06785b0 https://doi.org/10.1253/circj.68.355

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Increased Circulating Matrix Metalloproteinase-2 in Patients With Hypertrophic Cardiomyopathy With Systolic Dysfunction

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Increased Circulating Matrix Metalloproteinase-2 in Patients With Hypertrophic Cardiomyopathy With Systolic Dysfunction

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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