Key result
In patients with myocarditis, serum MMP-2, MMP-3, and TIMP-2 levels negatively correlated with left-ventricular ejection fraction and estimated glomerular filtration rate (p < 0.05).
Why the study?
Imbalances between MMPs and TIMPs contribute to cardiovascular and kidney diseases, but their levels and relationship to renal function in myocarditis required evaluation.
Observational (n=45)
p-value: p=< 0.05
Elevated levels of MMP-2, MMP-3, and TIMP-2 correlate with reduced left ventricular ejection fraction and worse renal function in patients with myocarditis, suggesting a role in post-inflammatory remodeling and cardiorenal interactions.
Associations of MMP-2/3 and TIMP-2 with lower EF and eGFR in myocarditis are hypothesis-generating; prospective studies needed before biomarker use.
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Kobusiak−Prokopowicz et al. (2021) conducted an observational in Myocarditis (n=45). Serum levels of MMP-2, MMP-3, MMP-9, and TIMP-2 was evaluated on Correlation with ejection fraction and renal function (eGFR) (p=< 0.05). In patients with myocarditis, serum MMP-2, MMP-3, and TIMP-2 levels negatively correlated with left-ventricular ejection fraction and estimated glomerular filtration rate (p < 0.05).
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