In patients with hypertrophic cardiomyopathy, enhanced collagen I synthesis and inhibition of MMP-1 and MMP-2 contribute to passive diastolic dysfunction.
As compared with controls, collagen turnover is enhanced in HCM patients. As collagen I synthesis prevails over degradation and MMP-1 and MMP-2 are inhibited, passive diastolic dysfunction occurs in patients with HCM.
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Circulation
Federico II University Hospital
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Lombardi et al. (Tue,) studied this question.