What does this research mean for the field?

Hypertrophic cardiomyopathy patients exhibit enhanced collagen turnover, where prevailing collagen I synthesis and MMP-1/MMP-2 inhibition drive passive diastolic dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 9, 2003

Myocardial Collagen Turnover in Hypertrophic Cardiomyopathy

Read Full Paperexternally

Structured PICO

Population

Patients with hypertrophic cardiomyopathy (HCM)

Comparator

Controls

Outcome

Collagen turnover and passive diastolic dysfunctionsurrogate

In patients with hypertrophic cardiomyopathy, enhanced collagen I synthesis and inhibition of MMP-1 and MMP-2 contribute to passive diastolic dysfunction.

Abstract

As compared with controls, collagen turnover is enhanced in HCM patients. As collagen I synthesis prevails over degradation and MMP-1 and MMP-2 are inhibited, passive diastolic dysfunction occurs in patients with HCM.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Lombardi et al. (Tue,) studied this question.

synapsesocial.com/papers/69bc1f01cd265641a06785b1 — DOI: https://doi.org/10.1161/01.cir.0000090687.97972.10

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease· 2000 · 443 citations
Lisinopril-Mediated Regression of Myocardial Fibrosis in Patients With Hypertensive Heart Disease· 2000 · 642 citations
Chromosomal aberrations and neutrophil activation induced by reperfusion in the ischaemic human heart· 1993 · 74 citations
Angiotensin II Blockade Reverses Myocardial Fibrosis in a Transgenic Mouse Model of Human Hypertrophic Cardiomyopathy· 2001 · 384 citations
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.· 1978 · 7,472 citations

Authors

Raffaella Lombardi

Heart Failure & Transplant

Sandro Betocchi

Heart Failure & Transplant

Maria Angela Losi

Cardiac Imaging

Journals

Circulation

Actions

Institutions

Federico II University Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Myocardial Collagen Turnover in Hypertrophic Cardiomyopathy

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider