In patients with hypertrophic cardiomyopathy, enhanced collagen I synthesis and inhibition of MMP-1 and MMP-2 contribute to passive diastolic dysfunction.
As compared with controls, collagen turnover is enhanced in HCM patients. As collagen I synthesis prevails over degradation and MMP-1 and MMP-2 are inhibited, passive diastolic dysfunction occurs in patients with HCM.
Lombardi et al. (2003) studied this question.