Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis

Key Points

• The aim is to evaluate the anticancer properties of benzoyl hydrazone derivatives, focusing on their ability to induce apoptosis in cancer cells.
• Synthesis of benzoyl hydrazone derivatives
• Evaluating antiproliferative activity in gastric cancer cells
• Assessment of ROS accumulation and mitochondrial dysfunction
• Compound Q-11 exhibits potent nanomolar antiproliferative activity
• Induces accumulation of reactive oxygen species
• Results in mitochondrial dysfunction and cytoskeletal disruption