Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis

Rongbin Wei; Xin Wang; Yamin Ding; Suting Zhu; Richmond Kwame Frimpong Asiedu; Meng Li; Haitao Qian; Yifei Gu; Bailing JIANG

doi:10.1039/d5md01046b

January 1, 2026RSC Medicinal Chemistry

Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis

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Key Points

The aim is to evaluate the anticancer properties of benzoyl hydrazone derivatives, focusing on their ability to induce apoptosis in cancer cells.
Synthesis of benzoyl hydrazone derivatives
Evaluating antiproliferative activity in gastric cancer cells
Assessment of ROS accumulation and mitochondrial dysfunction
Compound Q-11 exhibits potent nanomolar antiproliferative activity
Induces accumulation of reactive oxygen species
Results in mitochondrial dysfunction and cytoskeletal disruption

Implication

Shows benzoyl hydrazone derivatives induce apoptosis in cancer cells, suggesting a potential new cancer treatment.

Abstract

Compound Q-11 shows potent nanomolar antiproliferative activity in gastric cancer cells and induces ROS accumulation, mitochondrial dysfunction and cytoskeletal disruption.

Discussion

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Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/69c37b33b34aaaeb1a67d5f2 https://doi.org/10.1039/d5md01046b

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Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis and biological evaluation of benzoyl hydrazone derivatives as anticancer agents inducing ROS-associated mitochondrial apoptosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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