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June 19, 2026RSC Medicinal Chemistry

Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's disease

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Authors

NGNing GuoFWFeng WangYWYue Wang

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Overview

Randomized trial demonstrates real-time visualization of Alzheimer's pathology through a fluorescent probe targeting butyrylcholinesterase activity, indicating significant implications for...

Key Points

  • The aim is to develop a fluorescent probe that monitors butyrylcholinesterase activity in Alzheimer's disease models.
  • Developed LY36, a fluorescent probe sensitive to environmental changes.
  • Integrated selective inhibition of butyrylcholinesterase (BChE) for testing in biological models.
  • Monitored fluorescence in live samples to visualize Alzheimer's pathology.
  • Successfully visualized BChE activity in live biological models.
  • Demonstrated real-time changes in fluorescence correlating with Alzheimer's disease progression.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6a34e06865a5b0777af2f02fhttps://doi.org/10.1039/d6md00363j
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