Apical Cytoskeleton Orchestrates the Coordination of Multiple Cilia in Tracheal Epithelial Cells

Key Points

• To investigate the orchestration of cilia coordination in tracheal epithelial cells by the apical cytoskeleton.
• Utilized genetically modified fluorescently labeled mice
• Applied high-resolution live imaging techniques
• Examined microtubules and intermediate filaments in relation to basal body organization
• Identified a role for microtubules and intermediate filaments in organizing basal bodies and their orientation
• Showed that cilia coordination is influenced by the differentiation stage of epithelial cells