Capilliposide from Lysimachia capillipes Hemsl. shows anti-inflammatory and anti-pyretic effects via the MAPK/iNOS/NF- κ B pathway

Key Points

• To evaluate the anti-inflammatory and anti-pyretic effects of capilliposide from Lysimachia capillipes through specific molecular pathways.
• In vitro experiments to assess anti-inflammatory effects
• In vivo experiments to evaluate anti-pyretic effects
• Analysis of the MAPK/iNOS/NF-κB signaling pathway involved in these effects
• Capilliposide showed significant anti-inflammatory effects both in vivo and in vitro
• The compound effectively reduced fever in animal models
• Mechanistic studies confirmed involvement of the MAPK/iNOS/NF-κB pathway