To evaluate the anti-inflammatory and anti-pyretic effects of capilliposide from Lysimachia capillipes through specific molecular pathways.
In vitro experiments to assess anti-inflammatory effects
In vivo experiments to evaluate anti-pyretic effects
Analysis of the MAPK/iNOS/NF-κB signaling pathway involved in these effects
Capilliposide showed significant anti-inflammatory effects both in vivo and in vitro
The compound effectively reduced fever in animal models
Mechanistic studies confirmed involvement of the MAPK/iNOS/NF-κB pathway
Abstract
In summary, our results demonstrated that LC exhibited excellent anti-inflammatory and anti-pyretic effects in vivo and in vitro through MAPK/inducible nitric oxide synthase/NF-κB pathway.