What question did this study set out to answer?

The research aims to develop a practical method for difluoroalkylating and cyclizing coumarin derivatives using visible light.

March 29, 2026Organic Chemistry Frontiers0 citations

Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin4,3-bpyridinones

JYJinwei YuanHenan University of Technology SZShi-Long ZhangHenan University of Technology XWXin-Ya WangHenan University of Technology

Key Points

The research aims to develop a practical method for difluoroalkylating and cyclizing coumarin derivatives using visible light.
Utilized visible light to drive radical reactions.
Employed bromodifluoromethylphosphonium bromide as a radical precursor.
Focused on the synthesis of 4-(N-alkyl-N-acrylamido)coumarins.
Successfully created difluoroalkylated 4,5-fused coumarins.
Developed a rapid construction protocol for these compounds.
Demonstrated the potential for broader applications in molecular synthesis.

Abstract

An efficient and practical visible-light-driven cascade difluoroalkylation/cyclization of 4-( N -alkyl- N -acrylamido)coumarins has been developed using readily accessible bromodifluoromethylphosphonium bromide (Ph 3 PCF 2 H + Br - ) as a difluoromethyl radical precursor. This protocol enables the rapid construction of...

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