Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin[4,3-b]pyridinones

Jinwei Yuan; Shi-Long Zhang; Xin-Ya Wang; Meng Yan; Yongmei Xiao; Donghui Wei; Lingbo Qu

doi:10.1039/d6qo00192k

January 1, 2026Organic Chemistry Frontiers

Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin[4,3-b]pyridinones

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Key Points

The research aims to develop a practical method for difluoroalkylating and cyclizing coumarin derivatives using visible light.
Utilized visible light to drive radical reactions.
Employed bromodifluoromethylphosphonium bromide as a radical precursor.
Focused on the synthesis of 4-(N-alkyl-N-acrylamido)coumarins.
Successfully created difluoroalkylated 4,5-fused coumarins.
Developed a rapid construction protocol for these compounds.
Demonstrated the potential for broader applications in molecular synthesis.

Implication

An efficient technique demonstrates the construction of difluoroalkylated compounds using visible light, suggesting broad synthetic applications.

Abstract

An efficient and practical visible-light-driven cascade difluoroalkylation/cyclization of 4-( N -alkyl- N -acrylamido)coumarins has been developed using readily accessible bromodifluoromethylphosphonium bromide ([Ph 3 PCF 2 H] + Br - ) as a difluoromethyl radical precursor. This protocol enables the rapid construction of...

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Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69c8c384de0f0f753b39e4cc https://doi.org/10.1039/d6qo00192k

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Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin[4,3-b]pyridinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Visible-Light-Driven Radical Cascade Cyclization of 4-(N-Alkyl-Nacrylamido)coumarins: Access to Difluoroalkylated 4,5-Fused Coumarins and Coumarin[4,3-b]pyridinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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