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January 1, 2025Organic & Biomolecular Chemistry

Visible-Light-Promoted Tandem Radical Fluoroalkylation/ Cyclization to Access Fluoroalkyl-Containing Chromones/Chroman-4-ones

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Authors

YRYuanyuan RenYZYuxiu ZhouXPXiaona Pan

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Overview

Visible-light-induced radical fluoroalkylation forms fluoroalkyl-substituted chromones, suggesting new synthetic pathways.

Key Points

  • The reaction efficiently produces fluoroalkyl-substituted chromones and chroman-4-ones.
  • Using CF3Br and dichloroethane, the process yields several derivatives in high efficiency.
  • This approach employs visible-light promotion with fac-IrIII(ppy)3 as a key catalyst.
  • The findings may enhance the development of novel fluorinated compounds and materials.

Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/68af4eb4ad7bf08b1ead7569https://doi.org/10.1039/d5ob01148e
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